Christian McCaffrey Leaves With Leg Injury

49ers RB Christian McCaffrey exited in the second quarter of Sunday night's game vs. the Bills with an apparent right leg injury. He went down on his own with no contact. We'll update his status when we know more.

Update: McCaffrey is officially questionable to return with a knee injury.

Update: McCaffrey won't return, HC Kyle Shanahan said in an interview before the second half started.