Bills RB LeSean McCoy (thumb) practiced for the 2nd straight day on Thursday. RB Mike Gillislee, meanwhile, sat out after tweaking his hamstring on Wednesday. At this point, it looks like McCoy has the better chance of playing against the Jaguars this weekend. We'll have another update on both guys tomorrow.

Bills RB Karlos Williams (shoulder) is out for Sunday’s game against the Eagles. RB LeSean McCoy will see as many touches as he can handle vs. his former team.

Contradicting a previous item, Bills HC Rex Ryan said after Sunday's win over Miami that RB LeSean McCoy is playing on "one and a half legs," according to Tyler Dunne of The Buffalo News. Ryan reportedly added that McCoy is dealing with significant pain in his troublesome hamstring. That would explain his slow start, as well as Karlos Williams' 1-carry edge against the Dolphins. It's worth noting that Ryan had previously exuded almost nothing but confidence for McCoy's health status. Perhaps we'll see more of a timeshare in the coming weeks, especially after Williams' big Week 3. Ryan said the team hasn't considered sitting McCoy to get him back to 100%, but McCoy was more non-committal. "We got to look at everything," he said. "We'll figure it out. I'm not sure right now. I don't have a definite answer. We'll see what's going on." It's a situation to watch, and Williams should be picked up in any fantasy football league of at least moderate depth. If you own McCoy and someone else owns Williams, consider checking on the trade price for the rookie.