Niners Edge Mykel Williams tore the ACL in his right knee in Sunday's win over the Giants. HC Kyle Shanahan told reporters Monday that there's some damage to the lateral meniscus in the knee as well but that Williams suffered no further ligament damage.

Niners LB Fred Warner fractured and dislocated his right ankle in Sunday's loss to the Buccaneers, HC Kyle Shanahan announced after the game. He'll have surgery and miss the rest of the season.

Niners HC Kyle Shanahan told reporters Monday that Edge Nick Bosa tore his right ACL in Sunday's win over the Cardinals. Shanahan said after the game that a sideline ACL test gave them hope the ligament might be intact. But Bosa will now miss the rest of the season.

Niners Edge Nick Bosa left Sunday's win over the Cardinals with a right knee injury, and there's reason to believe it could be serious. Bosa flashed a thumbs down toward someone in the stands as he limped to the locker room after leaving in the first quarter.

ESPN's Adam Schefter reports that 49ers S Malik Mustapha tore his right ACL in the team's season finale. ESPN's Nick Wagoner says, "There is no definitive timeline on Mustapha's return, but -- given how late in the year the injury occurred -- it's unlikely he will be ready at the start of the season." Wagoner added that the injury is "related" to the ACL tear he suffered in January 2022, while at Wake Forest.

The 49ers spent the 11th pick of the NFL Draft on Georgia Edge Mykel Williams. The former five-star recruit arrived with the talent and flashed it in a solid true freshman season. That included 7 tackles for loss, 4.5 sacks, and 28 total tackles, which wound up as a career high for his college years. And that's the problem: He never progressed. Williams dealt with an ankle injury that he tweaked multiple times in 2024, which likely limited his production. But it's disappointing that such a heralded recruit -- and a talent that clearly impressed -- leaves Georgia with no truly impressive production. The positive: Williams hasn't even turned 21 yet.

The Broncos landed LB Dre Greenlaw in free agency with a three-year, $31.5 million deal. That positions him as Denver's highest-paid LB and marked a noteworthy investment into a 28-year-old (on May 25) who missed nearly all of last season coming off his Achilles' tear in the Super Bowl. The 49ers reportedly made a late push to retain Greenlaw. Instead, his move shakes up two LB groups.

Niners LB Dre Greenlaw appears likely to miss the final two games of the season with soreness in his calf. That's, of course, a more significant issue for Greenlaw than it might be for others because he's coming off an Achilles' tear from last year's Super Bowl. Greenlaw returned to play 30 snaps in Week 15, his first action since the injury. But he made it through just 4 snaps in Sunday's loss to the Dolphins.

Niners Edge Nick Bosa and LB Dre Greenlaw are active for today's game against the Dolphins. Both entered the day questionable but appeared likely to play. LB De'Vondre Campbell says he doesn't care.

Niners Edge Nick Bosa and LB Dre Greenlaw are active for tonight's game against the Rams. Bosa returns after missing the past three games with an oblique injury. He managed just a single limited practice, though, in a walkthrough. Bosa remains a risky play for IDP lineups. Greenlaw's making his 2024 debut. He has been out since suffering an Achilles' tear in the Super Bowl. That makes it tough to know what kind of playing time we can expect from the LB. He's best left on fantasy benches this week. The San Francisco defense can only benefit from getting the stars back, though.

Niners LB Dre Greenlaw is questionable for Thursday night's game against the Rams after putting in a full practice Wednesday. It was merely a walkthrough, but also the first time Greenlaw has been listed as a full participant since returning to practice ahead of the Week 13 game. Edge Nick Bosa is also questionable after returning to a limited practice Wednesday. San Francisco also ruled out rookie S Malik Mustapha.

The 49ers expect to get LB Dre Greenlaw back for the Week 15 game against the Rams. He has put in limited practices each day of the past two weeks but was still ruled out for this Sunday's game against the Bears. Greenlaw, of course, has yet to play this season because he's recovering from the Achilles' rupture he suffered in the Super Bowl.

The 49ers have activated S Talanoa Hufanga from IR. He put in limited practices all week and is officially questionable. But Jennifer Lee Chan of NBC Sports Bay Area on Friday called him "set to return" for Sunday's game against the Bears.

The 49ers expect Edge Nick Bosa to miss his third straight game this week. Bosa's officially doubtful after missing all three practice days with the hip and oblique injuries that cost him the past two games. He has participated in just one practice since Week 10.

Niners CB Charvarius Ward (Knee) is inactive for tonight's game against the Seahawks. It's a bit surprising after he managed limited practices the past two days and entered the night questionable. That leaves San Francisco without its top corner against the league's leading offense in passing volume. Ward's absence particularly helps DK Metcalf and Tyler Lockett on the outside.

Niners LB Fred Warner (ankle) is officially active for today's game against the Cardinals, as expected. CB Isaac Yiadom (thigh) is also active after entering the day questionable.

Niners LB Fred Warner is expected to play through his ankle sprain today against the Cardinals, according to multiple reports. There might still be some risk of limited playing time, but this early report indicates that he's better than a game-time decision. He appeared to be moving well in his Friday return to practice. I moved Warner back up the Week 5 LB rankings on this morning's news. He'll obviously carry some re-injury risk -- but also plenty of fantasy upside. Weigh both vs. your other IDP lineup options.

Niners HC Kyle Shanahan told reporters Monday that DT Javon Hargrave is expected to need surgery for a triceps tear and miss the rest of the season.

Niners Edge Nick Bosa (rib) and CB Charvarius Ward (hamstring, knee) are active for today's game against the Rams. Both look ready for IDP use as planned.

The 49ers left S Talanoa Hufanga off the final Week 3 injury report for the first time this season. That should mean the first action for Hufanga since he suffered an ACL tear in Week 11 last season. I wouldn't bet on the safety getting a full workload, and there's likely more risk than reward to playing Hufanga in IDP lineups. But we'll see how quickly he can ramp back up to full duty. Expect Hufanga to reclaim the position that George Odum and Malik Mustapha have covered the first two weeks.